Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10895578 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2014 | 14 Pages |
Abstract
Low-grade gliomas represent the most frequent brain tumors arising during childhood. They are characterized by a broad and heterogeneous group of tumors that are currently classified by the WHO according to their morphological appearance. Here we review the clinical features of these tumors, current therapeutic strategies and the recent discovery of genomic alterations characteristic to these tumors. We further explore how these recent biological findings stand to transform the treatment for these tumors and impact the diagnostic criteria for pediatric low-grade gliomas.
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Authors
Guillaume Bergthold, Pratiti Bandopadhayay, Wenya Linda Bi, Lori Ramkissoon, Charles Stiles, Rosalind A. Segal, Rameen Beroukhim, Keith L. Ligon, Jacques Grill, Mark W. Kieran,