| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10895579 | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2014 | 9 Pages |
Abstract
Sequence editing provides an additional regulatory layer of cancer initiation and progression that may be amenable to therapeutic design. Although editing of both RNA and DNA substrates has been known to occur for some time, the extent and implications of these modifications have been grossly underappreciated until recent genome-wide and disease-association studies were reported. This review highlights the cellular processes controlled by sequence editing, their implications in normal and cancerous states and considers potential targeted therapeutic strategies.
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Cancer Research
Authors
Lotta Avesson, Guy Barry,