Article ID Journal Published Year Pages File Type
10895631 Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2011 12 Pages PDF
Abstract
Signal transducers and activators of transcription (STATs) are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes. These include cell growth, cell differentiation, apoptosis and immune responses. Dysregulation of STATs, either due to constitutive activation or function impairment, can have, therefore, deleterious biological consequences. This review places particular emphasis on their structural organization, biological activities and regulatory mechanisms most commonly utilized by cells to control STAT-mediated signalling. STATs also play important roles in cancer and immune deficiencies and are thus being exploited as therapeutic targets.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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