Article ID Journal Published Year Pages File Type
10897903 Cancer Genetics and Cytogenetics 2005 5 Pages PDF
Abstract
We describe a case of acute leukemia in a child with an unusual immunophenotype and a novel cytogenetic abnormality. The leukemia blasts expressed myeloid, natural killer and B-lineage associated antigens. Cytogenetics showed the presence of a novel unbalanced chromosomal translocation, der(19)t(12;19)(q12;p13.3). The patient achieved and maintained remission with myeloid-directed chemotherapy. The differential diagnosis of the immunophenotype and the potential fusion genes are discussed.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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A der(19)t(12;19)(q12;p13.3) in a case of pediatric acute leukemia with unusual immunophenotype
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