| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10898018 | Cancer Genetics and Cytogenetics | 2005 | 5 Pages |
Abstract
Intrahepatic cholangiocarcinoma (ICC) arises from epithelial cells in the intrahepatic bile duct. Until now, only few reports have been available concerning the genetic changes during the progression of ICC. In this study, we analyzed chromosomal aberrations in 19 frozen ICC samples using comparative genomic hybridization. The common chromosomal gains were observed in 8q22â¼qter (11 cases, 58%), 5p14â¼pter (32%), 2q33â¼qter (26%), 7p (26%), 17q21â¼q22 (26%), 18q12â¼q21 (26%), and 19q13.1 (26%). DNA amplification was identified in nine tumors (47%). Chromosomal loss was found in Y (60%), 1p34â¼pter (37%), 4q(32%), 18q21â¼qter (32%) 19p (32%), X (32%), 5q11â¼q14 (26%), 8p(26%), 9p (26%), and 17p (26%). Chromosomal aberrations identified in this study provide candidate regions involved in the tumorigenesis and progression of ICC.
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Authors
Kyung-Ok Uhm, Young-Nyun Park, Ji-Young Lee, Dong-Seop Yoon, Sun-Hwa Park,