| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10898088 | Cancer Genetics and Cytogenetics | 2005 | 5 Pages |
Abstract
In the present paper, we report a molecular cytogenetic study of 1q abnormalities associated with t(8;14)(q24;q32) in an adult common B acute lymphoblastic leukemia case with FAB-L2 morphology. The use of appropriate molecular cytogenetic probes allowed us to detect 13 different subclones showing heterogeneous chromosome 1 abnormalities. A complex pattern of rearrangements consisting of translocations, duplications, and inversions was observed. Breakage-fusion-bridge cycle and jumping translocation are hypothesized to have been involved in generating the large number of aberrations we detected.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Giorgina Specchia, Francesco Albano, Luisa Anelli, Antonella Zagaria, Arcangelo Liso, Alessandra Pannunzio, Nicoletta Archidiacono, Vincenzo Liso, Mariano Rocchi,