Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10899282 | Cancer Letters | 2016 | 10 Pages |
Abstract
The importance of angiogenesis in pancreatic ductal adenocarcinoma (PDAC) and its therapeutic potential have been explored in both pre-clinical and clinical studies. Human PDACs overexpress a number of angiogenic factors and their cognate high-affinity receptors, and anti-angiogenic agents reduce tumor volume, metastasis, and microvessel density (MVD), and improve survival in subcutaneous and orthotopic pre-clinical models. Nonetheless, clinical trials using anti-angiogenic therapy have been overwhelmingly unsuccessful. This review will focus on these pre-clinical and clinical studies, the potential reasons for failure in the clinical setting, and ways these shortcomings could be addressed in future investigations of angiogenic mechanisms in PDAC.
Keywords
MVDPlGFTCGAKPCVEGFR-3VEGF-BPDGFRBBRAFKICCDKN2AIL-8ECMNICDVEGFR-1PDGFVEGFR-2NIHVEGF-AVEGFRHRGHSPGPDGFRNRP1CSF1RGlypican-1FOLFIRINOXpancreatic cancer cellGPC1FGFR-1FDATrp53TGF-βPDACNCICAFGEMMRNA-seqKRASFGFVEGFAPCCHIF-1αORRFGF2EGFRdll4PFsPancreatic ductal adenocarcinomaangiopoietinAngiogenesisThe cancer genome atlasImmunohistochemistryIHCProgression free survivaloverall survivalMicrovessel densityRNA sequencingNotch intracellular domainKirsten rat sarcoma viral oncogene homologFood and Drug AdministrationPancreatic cancerImmune cellEndothelial cellfibroblast growth factor 2confidence intervalVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Vascular endothelial growth factor (VEGF)platelet-derived growth factorfibroblast growth factorcancer associated fibroblastNational Institutes of HealthExtracellular matrixgenetically engineered mouse modelcyclin-dependent kinase inhibitor 2ANational Cancer Instituteobjective response ratehazard rationeuropilin-1platelet-derived growth factor receptor betaplatelet-derived growth factor receptorvascular endothelial growth factor receptorEpidermal growth factor receptor
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Authors
Kelly E. Craven, Jesse Gore, Murray Korc,