Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10899326 | Cancer Letters | 2016 | 7 Pages |
Abstract
In spite of the numerous encouraging preclinical evidence, the very small number of clinical trials investigating NP possible involvement in the radiotherapy clinical practice suggests a physicians' unwillingness. Many prerequisites seem necessary including define biological mechanisms of NP radiosensitization pathways and of NP clearance. NP biocompatibility and toxicities should be better investigated to select, among the extensive range of possible systems, the harmless and most efficient one, and to finally come to a safe and successful clinical use. The present review focuses on the various interests of NP in the radiotherapy area and proposes a discussion about their role in the future clinical practice.
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Authors
Chloé Rancoule, Nicolas Magné, Alexis Vallard, Jean-Baptiste Guy, Claire Rodriguez-Lafrasse, Eric Deutsch, Cyrus Chargari,