Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10899406 | Cancer Letters | 2015 | 11 Pages |
Abstract
Over the last decade there has been a dramatic shift in the focus of cancer research toward understanding how the body's immune defenses can be harnessed to promote the effectiveness of cytotoxic anti-cancer therapies. The ability of ionizing radiation to elicit anti-cancer immune responses capable of controlling tumor growth has led to the emergence of promising combination-based radio-immunotherapeutic strategies for the treatment of cancer. Herein we review the immunoadjuvant properties of localized radiation therapy and discuss how technological advances in radio-oncology and developments in the field of tumor-immunotherapy have started to revolutionize the therapeutic application of radiotherapy.
Keywords
IDOCTLA-4TGF-βTNFRAE-1SASPMDSCSABRMCP-1MRTSDF-1DAMPCrtPD-1PD-L1cytotoxic T lymphocyte antigen-4damage-associated molecular patternsAnti-tumor immunityimmunotherapyinterferonIFNindoleamine 2,3-dioxygenaseionizing radiationtransforming growth factor-βGrayLinear quadraticICDRadiotherapyCancerDendritic cellMyeloid derived suppressor cellsstromal cell-derived factor 1tumor necrosis factorSenescence-associated secretory phenotypemajor histocompatibility complexMHCProgrammed death-1programmed death-ligand 1Immunogenic cell deathAntibodymonocyte chemoattractant protein-1calreticulin
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Authors
Suresh J. Haikerwal, Jim Hagekyriakou, Michael MacManus, Olga A. Martin, Nicole M. Haynes,