Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10899459 | Cancer Letters | 2015 | 10 Pages |
Abstract
Intratumoral heterogeneity is a recently recognized but important feature of cancer that underlies the various biocharacteristics of cancer tissues. The advent of next-generation sequencing technologies has facilitated large scale capture of genomic data, while the recent development of single-cell sequencing has allowed for more in-depth studies into the complex molecular mechanisms of intratumoral heterogeneity. In this review, the recent advances and current challenges in single-cell sequencing methodologies are discussed, highlighting the potential power of these data to provide insights into oncological processes, from tumorigenesis through progression to metastasis and therapy resistance.
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Authors
Hai-jian Sun, Jian Chen, Bing Ni, Xia Yang, Yu-zhang Wu,