Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10899562 | Cancer Letters | 2015 | 43 Pages |
Abstract
Skin cancers are by far the most common malignancy of humans, particularly in the white population. The growing incidence of cutaneous malignancies has heralded the need for multiple treatment options. Although surgical modalities remain the mainstay of treatment, new research and fresh innovation are still required to reduce morbidity and mortality. Approaches for skin cancer may pass through new technological methods instead of new molecules. The first part of this paper provides a review of the state of the art regarding skin cancer disease as well as epidemiology data. Then, it describes the gold standards of the current recommended therapies worldwide and the actual needs of these patients. This is the first paper that highlights the novel and future therapeutic perspectives for the treatment of skin malignancies, new therapeutic agents and promising technological approaches, from nanotechnology to immunotherapy.
Keywords
PEIPLGANF-κBPI3K5-FUEGFTAAPD-1CPPSCCCNTNIRECTNSCPD-L1PDTPTTCOX-2MSCBCCSLNNLCHspAPCPTDEPTTLRCNPTGFNLSSCFc-kitHIFU5-ALARTKcytotoxic T-lymphocyte-associated antigen 4NMSCMSHMNPMNTGNPMRgFUSCyclooxygenase IInsPEFPhosphatidylinositol-3-kinasesMagnetic resonance-guided focused ultrasoundTNFCTLA-4nonmelanocytic skin cancerSKP1-CUL1-F-box proteinSiNp5-Aminolevulinic acidMAPKROStumor-associated antigenHyaluronic acidElectrochemotherapyMRIimmunotherapyinterferonIFNinterleukinPolymersMagnetic resonance imagingToll-like receptorNanostructured lipid carrierProtein transduction domainPhotodynamic therapynuclear localization sequenceNGOSkin cancerDendritic cellNeural stem cellMesenchymal stem cellantigen presenting cellhigh intensity focused ultrasoundepidermal growth factortumor growth factortumor necrosis factornuclear factor kappa-light-chain-enhancer of activated B cellsPhototherapyPhotothermal therapyUltrasound5-fluorouracilTRAILprogrammed cell death ligand 1TNF-related apoptosis-inducing ligandCutaneous malignant melanomaNanosecond pulsed electric fieldsGold nanoparticleNanoparticleNanoparticlesCerium oxide nanoparticleSilica nanoparticleSolid lipid nanoparticleMagnetic nanoparticleCarbon nanotubeNear-infraredquantum dotMelanocyte-stimulating hormoneHeat shock proteinprogrammed cell death protein 1mitogen-activated protein kinaseCold atmospheric plasmaPolyethyleniminepolyethylene glycolPEGCell-penetrating peptideBasal cell carcinomaSquamous cell carcinomaCaPReactive oxygen speciesReceptor Tyrosine Kinase
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Authors
M.C.F. Simões, J.J.S. Sousa, A.A.C.C. Pais,