Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10899583 | Cancer Letters | 2015 | 13 Pages |
Abstract
Breast cancer is the most common malignancy amongst women worldwide but despite enormous efforts to address this problem, there is still limited success with most of the current therapeutic strategies. The current study describes the anti-cancer activity of a binuclear palladacycle complex (AJ-5) in oestrogen receptor positive (MCF7) and oestrogen receptor negative (MDA-MB-231) breast cancer cells as well as human breast cancer stem cells. AJ-5 is shown to induce DNA double strand breaks leading to intrinsic and extrinsic apoptosis and autophagy cell death pathways which are mediated by the p38 MAP kinase. This study provides evidence that AJ-5 is potentially an effective compound in the treatment of breast cancer.
Keywords
CSCPalladacyclesγH2AXPARPLC3p70S6KERKBcl-2mTORFACSMAPKp53 upregulated modulator of apoptosisp38 MAPKAutophagyBaxApoptosisBCsBreast cancerBreast cancer cellcancer stem cellCancer stem cellsfluorescence activated cell sortingB-cell lymphoma-2Bcl-2-associated X proteinmicrotubule-associated proteinmitogen-activated protein kinasePoly(ADP-ribose) polymerasePUMACaspasesextracellular signal-regulated kinaseoestrogen receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Saeb Aliwaini, Jade Peres, Wendy L. Kröger, Angelique Blanckenberg, Jo de la Mare, Adrienne L. Edkins, Selwyn Mapolie, Sharon Prince,