Article ID Journal Published Year Pages File Type
10899701 Cancer Letters 2015 9 Pages PDF
Abstract

- SIRT2 inhibitor destabilizes Snail and then induces G1 arrest in HCT116 colon cancer cells.
- The mechanism by which SIRT2 inhibitor destabilizes Snail is possibly dependent on NF-kappaB/CSN2 pathway.
- SIRT2 inhibitor is a potential therapeutic agent for the treatment of colon cancer.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Preview
AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells
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