| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10899774 | Cancer Letters | 2015 | 7 Pages |
Abstract
The covalent attachment of β-D-N-acetylglucosamine monosaccharides (O-GlcNAc) to serine/threonine residues of nuclear and cytoplasmic proteins is a major regulatory mechanism in cell physiology. Aberrant O-GlcNAc modification of signaling proteins, metabolic enzymes, and transcriptional and epigenetic regulators has been implicated in cancer. Relentless growth of cancer cells requires metabolic reprogramming that is intertwined with changes in the epigenetic landscape. This review highlights the emerging role of protein O-GlcNAcylation at the interface of cancer metabolism and epigenetics.
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Authors
Jay Prakash Singh, Kaisi Zhang, Jing Wu, Xiaoyong Yang,