| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10899825 | Cancer Letters | 2014 | 8 Pages |
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively for analgesic and antipyretic treatments. In addition, NSAIDs reduce the risk and mortality to several cancers. Their mechanisms in anti-tumorigenesis are not fully understood, but both cyclooxygenase (COX)-dependent and -independent pathways play a role. We and others have been interested in elucidating molecular targets of NSAID-induced apoptosis. In this review, we summarize updated literature regarding cellular and molecular targets modulated by NSAIDs. Among those NSAIDs, sulindac sulfide and tolfenamic acid are emphasized in this review because these two drugs have been well investigated for their anti-tumorigenic activity in many different types of cancer.
Keywords
EGFRTGF-βbasic leucine zipper domainNAG-1PDE5FAPEGR-1bZIPNSAIDSCOXNSAIDtolfenamic acidArachidonic acidtransforming growth factor-betaEMTCHOPColorectal cancerSulindac sulfideNon-steroidal anti-inflammatory drugphosphodiesterase type 5early growth response-1familial adenomatous polyposisCRCEpithelial-mesenchymal transitionEpidermal growth factor receptor
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Authors
Jason L. Liggett, Xiaobo Zhang, Thomas E. Eling, Seung Joon Baek,