Combination of bendamustine and entinostat synergistically inhibits proliferation of multiple myeloma cells via induction of apoptosis and DNA damage response

Article ID	Journal	Published Year	Pages	File Type
10899937	Cancer Letters	2013	8 Pages	PDF

Abstract

âº Synergy of entinostat and bendamustine. âº Apoptosis and DNA damage. âº Novel therapy for MM.

Keywords

IGF-1 IGF-1R PARP HDACi CLL Bendamustine PI-3K entinostat MTS PAGE HDAC IC50 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt c-Jun N-terminal kinase MAPK DNA damage STAT polyacrylamide gel electrophoresis insulin-like growth factor-1 Enzyme-linked immunosorbent assay ELISA Apoptosis combination index inhibitory concentration 50 phosphoinositide 3-kinase Chronic lymphocytic leukemia signal transducers and activators of transcription Multiple myeloma Histone acetyltransferase histone deacetylase mitogen-activated protein kinase Poly(ADP-ribose) polymerase JAK HAT IGF-1 receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research

Combination of bendamustine and entinostat synergistically inhibits proliferation of multiple myeloma cells via induction of apoptosis and DNA damage response

Authors

Bo Cai, Hui Lyu, Jingcao Huang, Shuiliang Wang, Choon-Kee Lee, Chunji Gao, Bolin Liu,