| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10899965 | Cancer Letters | 2013 | 5 Pages |
Abstract
⺠Bit1 is a mitochondrial protein which is a part of an apoptosis pathway that is regulated by integrin-mediated cell attachment. ⺠Following loss of cell attachment, Bit1 is released to cytosol and induces a caspase-independent form of apoptosis. ⺠As an anoikis effector, Bit1 may function to turn off the anti-apoptotic TLE1-mediated transcriptional program. ⺠Accumulating evidences indicate that the Bit1 anoikis pathway may regulate the metastatic proficiency of malignant cells.
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Authors
Scott Jenning, Tri Pham, Shubha Kale Ireland, Erkki Ruoslahti, Hector Biliran,