| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10899978 | Cancer Letters | 2013 | 11 Pages |
Abstract
⺠We studied the anti-tumor mechanisms of mAb 8B6 specific to OAcGD2. ⺠Antibody 8B6 induces tumor cell cycle arrest and tumor cell apoptosis in vitro.. ⺠Antibody 8B6 triggers the mitochondrial apoptotic pathway with caspase 3 activation. ⺠Antibody 8B6's apoptotic properties results in tumor growth inhibition in vivo.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Denis Cochonneau, Mickaël Terme, Alexis Michaud, Mylène Dorvillius, Nicolas Gautier, Jihane Frikeche, Nidia Alvarez-Rueda, Gwenola Bougras, Jacques Aubry, François Paris, Stéphane Birklé,