Trefoil factor 1 suppression of E-CADHERIN enhances prostate carcinoma cell invasiveness and metastasis

Article ID	Journal	Published Year	Pages	File Type
10899994	Cancer Letters	2013	11 Pages	PDF

Abstract

âº TFF1 enhances prostate carcinoma cell migration and invasion. âº TFF1 reduces expression of E-CADHERIN in prostate carcinoma cells and E-CADHERIN rescue abrogates TFF1 stimulated migration. âº TFF1 enhances prostate carcinoma cell metastasis in a xenograft model. âº Inhibition of TFF1 using specific inhibitory antibodies or specific RNAi reduces prostate carcinoma cell invasion.

Keywords

FITC Trefoil factor 1 TFF1 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT PCA RNA interference RNAi epithelial to mesenchymal transition TUNEL EMT Prostate cancer fluorescein isothiocyanate Metastasis epithelial-to-mesenchymal transition

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research

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Trefoil factor 1 suppression of E-CADHERIN enhances prostate carcinoma cell invasiveness and metastasis

Authors

N.M. Bougen, N. Amiry, Y. Yuan, X.J. Kong, V. Pandey, L.J.P. Vidal, J.K. Perry, T. Zhu, P.E. Lobie,