OT-404, multi-targeted anti-cancer agent affecting tumor proliferation, chemo-resistance, and angiogenesis

► OT-404 is a putative anti-cancer agent that affects major cancer-associated processes. ► OT-404 effectively inhibits proliferation of various cancer cell lines. ► OT-404 enhances the sensitivity of various cancer cell lines to classical chemotherapeutic agents in vitro and in vivo. ► OT-404 inhibits cancer angiogenesis in the CAM and mice tumor models.