Article ID Journal Published Year Pages File Type
10900014 Cancer Letters 2013 11 Pages PDF
Abstract
► DLL4 positive immunoreactivity was observed in most cases of duct cells from tumor tissues. ► Chemo-drug distribution was broadly consistent with intratumoral blood perfusion. ► Defective angiogenesis caused by DLL4/Notch pathway induced the inefficient drug delivery. ► DLL4 enhanced chemoresistance through the angiogenesis dependent and independent mechanisms.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Authors
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