| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10900015 | Cancer Letters | 2013 | 11 Pages |
Abstract
⺠Sonic hedgehog pathway regulates pancreatic cancer stem cell characteristics. ⺠Inhibition of Gli transcription by GANT-61 suppresses pancreatic cancer stem cell characteristics and tumor growth. ⺠GANT-61 inhibits pluripotency maintaining factors Nanog, Oct-4, Sox-2 and cMyc. ⺠GANT-61 can be used for the management of pancreatic cancer by targeting pancreatic cancer stem cells.
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Authors
Junsheng Fu, Mariana Rodova, Sanjit K. Roy, Jay Sharma, Karan P. Singh, Rakesh K. Srivastava, Sharmila Shankar,