Article ID Journal Published Year Pages File Type
10900017 Cancer Letters 2013 8 Pages PDF
Abstract
► HER2 overexpression enhances AhR mRNA and protein levels. ► HER2/MEK/ERK signal increases transcription of AhR mRNA. ► AhR Inhibition reduces HER2-mediated induction of IL-6 mRNA and mammosphere formation. ► Results suggest HER2/AhR signaling is important for maintenance of cancer stem cells in HER2-overexpressing breast cancer cells.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Preview
HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription
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