Article ID Journal Published Year Pages File Type
10900018 Cancer Letters 2013 8 Pages PDF
Abstract
► The solubility of ZnPc was improved by using a Cremophor EL formulation. ► ZnPc mainly accumulated in mitochondria, lysosome and endoplasmic reticulum (ER). ► ZnPc triggered caspase-dependent apoptosis by elevating the intracellular ROS level. ► ZnPc induced cell cycle arrest in G2/M phase and decreased membrane potential (ΔΨm) in HepG2 cells.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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Intracellular distribution and mechanisms of actions of photosensitizer Zinc(II)-phthalocyanine solubilized in Cremophor EL against human hepatocellular carcinoma HepG2 cells
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