| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10900023 | Cancer Letters | 2013 | 10 Pages |
Abstract
⺠Steroid biosynthesis and/or their signaling pathways promote the growth of gliomas. ⺠The drug DK16 functions as an inhibitor of the enzyme 17b-hydroxysteriod dehydrogenase 3. ⺠DK16 modulates several oncogenic mediators causing a decrease in cell viability, proliferation and migration/invasion.âºDK16 induces growth arrest and apoptosis. ⺠DK16 demonstrates potent anti-neoplastic properties in the treatment of pediatric low grade gliomas.
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Authors
Norbert Fonya Ajeawung, René Maltais, Chris Jones, Donald Poirier, Deepak Kamnasaran,