| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10900029 | Cancer Letters | 2012 | 10 Pages |
Abstract
⺠The numbers of Th22 cells were increased in malignant pleural effusion when compared with those in blood. ⺠Each of IL-1β, IL-6 and TNF-α could promote the differentiation of Th22 cells from naïve CD4+ T cells. ⺠Th22 cells could be recruited into pleural space via CCL20-CCR6, CCL22-CCR4, or/and CCL27-CCR10 axes. ⺠IL-22 substantially and persistently promoted the proliferation and migratory activity of A549 cells. ⺠IL-22 could strongly facilitate intercellular adhesion of A549 cells to pleural mesothelial cell monolayers.
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Authors
Zhi-Jian Ye, Qiong Zhou, Wen Yin, Ming-Li Yuan, Wei-Bing Yang, Fei Xiang, Jian-Chu Zhang, Jian-Bao Xin, Xian-Zhi Xiong, Huan-Zhong Shi,