| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10900036 | Cancer Letters | 2012 | 8 Pages |
Abstract
⺠Silibin, a flavinoligand derived from Milk Thistle, is a dietary supplement reported to exert hepatoprotective effects. ⺠To date little evidence exists regarding potential detrimental effects associated with Milk Thistle. ⺠Our study employed a mouse model of hepatocellular carcinoma (HCC) concomitant with chronic alcohol and/or silibinin feeding. ⺠We demonstrate marginal hepatoprotective effects of silibinin in female mice in this model during early HCC progression. ⺠Silibinin exacerbated tumor progression in male mice in this model of HCC progression if combined with chronic alcohol intake.
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Authors
Elizabeth Brandon-Warner, Ashley L. Eheim, David M. Foureau, Tracy L. Walling, Laura W. Schrum, Iain H. McKillop,