| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10900067 | Cancer Letters | 2012 | 7 Pages |
Abstract
Colorectal cancer remains the most common cancer and the second leading cause of cancer mortality in Europe. There are a number of pathways that have been implicated in colorectal carcinogenesis, including TGF-beta (TGF-β)/Smad signalling pathway. The TGF-β pathway is involved in several biological processes, including cell proliferation, differentiation, migration and apoptosis. Here we review the role of TGF-β signalling cascade in colorectal carcinogenesis and provide some new molecular insights that may aid efforts towards targeted antitumor therapies.
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Cancer Research
Authors
Pavlos Lampropoulos, Adamantia Zizi-Sermpetzoglou, Spyros Rizos, Alkiviadis Kostakis, Nikolaos Nikiteas, Athanasios G. Papavassiliou,