Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10900084 | Cancer Letters | 2011 | 8 Pages |
Abstract
COX-2 and 5-LOX are up-regulated in ESCC. This study aims to determine the efficacy of COX-2 inhibitor, 5-LOX inhibitor and their combination on ESCC. Nimesulide can suppress cell growth and promote apoptosis, accompanied with a decrease of PGE2 production. AA861 has the similar effect with a down-regulation of LTB4. In animal experiment, the tumor volumes in drug-treated groups were significantly smaller with the lowest rates of Ki-67 positive cells. In conclusion, either COX-2 inhibitor or 5-LOX inhibitor can suppress ESCC. Dual inhibition of COX-2 and 5-LOX pathway may present a superior anticancer efficacy to either inhibition of COX-2 or 5-LOX alone.
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Authors
Shi Hai-yun, Lv Fu-jing, Zhu Sheng-tao, Wang Qing-gang, Zhang Shu-tian,