Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10900088 | Cancer Letters | 2011 | 8 Pages |
Abstract
We investigated the transcription levels, promoter methylation status and role as a tumor suppressor gene (TSG) of the cadherin CDH4 in nasopharyngeal carcinoma (NPC). The expression of CDH4 was decreased in NPC cell lines, xenografts and primary tumor biopsies. Promoter hypermethylation of CDH4 was detected in all five NPC cell lines, both NPC xenograft lines and 94.3% of primary tumors but not in any of the 12 normal epithelial samples. Loss of CDH4 expression could be restored by the methyltransferase inhibitor 5-aza-2â²-deoxycytidine in NPC cell lines. Ectopic expression of CDH4 in the NPC cell lines inhibits cell proliferation, colony formation, migration and elicit cell communication. CDH4 may be a novel putative TSG that can be frequently and tumor-specifically inactivated by its promoter methylation in NPC.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Chunping Du, Tingting Huang, Di Sun, Yingxi Mo, Haiyan Feng, Xiaoying Zhou, Xue Xiao, Nana Yu, Bo Hou, Guangwu Huang, Ingemar Ernberg, Zhe Zhang,