| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10900093 | Cancer Letters | 2011 | 9 Pages |
Abstract
We analyzed hepatocellular carcinoma (HCC) with progenitor cell features using hepatic stem/progenitor cell marker neural cell adhesion molecule (NCAM). Approximately 8.3% of the operated HCC cases expressed NCAM, and 22.3% of the HCC patients had soluble NCAM levels >1000 ng/ml (the “highly soluble” NCAM group). Soluble NCAM status was a significant independent factor predictive of long-term survival in patients with HCC, and high levels of soluble NCAM were significantly related to intrahepatic metastasis. The 140-kDa NCAM isoform was specifically detected in the “highly soluble” NCAM group of HCC patients and its related signals are potential drug targets for NCAM+ HCC.
Keywords
PVDFGPiGap43TGFPLCDAPIGAPDHNCAMFGFRCDC42DMEMFACSPBSCK19PIVKA-II4′ 6-diamidino-2-phenylindoleFRS2natural killerHCCα-fetoproteinepithelial mesenchymal transitiontransforming growth factorAFPEnzyme-linked immunosorbent assayELISAEMTRac-1Ras-related C3 botulinum toxin substrate 1cell division cycle 42cytokeratin 19phycoerythrinphospholipase Cfluorescence-activated cell sorterFynintrahepatic metastasisPhosphate-buffered salineneural cell adhesion moleculepolymerase chain reactionPCRgrowth-associated protein 43Polyvinylidene fluorideHepatocellular carcinomacholangiocellular carcinomaglyceraldehydes-3-phosphate dehydrogenaseglycosyl-phosphatidylinositolfibroblast growth factor receptor
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Authors
Atsunori Tsuchiya, Hiroteru Kamimura, Yasushi Tamura, Masaaki Takamura, Satoshi Yamagiwa, Takeshi Suda, Minoru Nomoto, Yutaka Aoyagi,