| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10900094 | Cancer Letters | 2011 | 6 Pages |
Abstract
Circulating glucose-regulated protein 78 (GRP78) autoantibodies represent potential biomarker of epithelial ovarian cancer. However there is relatively limited identification of these antibodies in response to ovarian cancer. Here, we were interested in characterization of these antibodies and into their role in tumor development. We first purified GRP78 autoantibodies from sera of patients with ovarian cancer, and then tested them on SKOV-3 ovarian cancer cell line. A decrease of invasion and an increase of H2O2-induced apoptosis of SKOV-3 cells were observed, suggesting their protective role against ovarian cancer cells.
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Authors
Marie Cohen, Patrick Petignat,