Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10900095 | Cancer Letters | 2011 | 9 Pages |
Abstract
D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Yung-Ning Yang, Kai-ming Chou, Wen-Yu Pan, Yih-wen Chen, Tsui-Chun Tsou, Ssu-Ching Yeh, Chun Hei Antonio Cheung, Li-Tzong Chen, Jang-Yang Chang,