Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10900183 | Cancer Letters | 2005 | 9 Pages |
Abstract
Melanoma shows the high rates of mortality, preferentially by metastasis, and the failure of chemotherapy. We inoculated 30 B16F10 Swiss mice with 5Ã105 melanocytes. The mice were then inoculated with 150,000; 300,000; 600,000 and 1,200,000 IU/mouse of interferon α. A count of the metastatic nodules of the lung surface and the microscopic study were made by image analysis on five histological sections, calculating the implantation percentage and tumoral growth and invasion index. Treatment with the three highest doses of interferon alpha resulted in a dose-dependent reduction of the number of metastatic nodules and invaded area. A correlation existing between the parameters studied and the different antitumoral effects observed.
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Authors
Cristina MartÃnez, Vicente Vicente, Ma Josefa Yáñez, Juana Ma GarcÃa, Manuel Canteras, Miguel Alcaraz,