| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10900206 | Cancer Letters | 2005 | 6 Pages |
Abstract
BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intravenous administration of both BAT antibodies significantly reduced the number of metastases and liver weights. Histological examinations demonstrated lymphocyte accumulation near remnant tumors and in tumor-free tissues of BAT treated mice. The efficacy of humanized BAT in the regression of hepatic metastases in human colorectal carcinoma has potential clinical use.
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Authors
Britta Hardy, Sara Morgenstern, Annat Raiter, Galina Rodionov, Ludmilla Fadaeev, Yaron Niv,