Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10900320 | Cancer Letters | 2005 | 8 Pages |
Abstract
Free radical and antioxidant parameters in healthy dogs (n=10) and dogs with non-Hodgkin lymphomas (n=11) were measured in blood and lymph node tissue samples before chemotherapy. Enzymatic and other biochemical measurements were performed. We found that (i) free radical concentrations based on ESR spectra of tissues correlated with higher proliferative character; (ii) lymphoma cases showed an impaired antioxidant status; (iii) tumors with low oxidative burst capacity and higher reduced/oxidized glutathione ratio responded better to chemotherapy; and (iv) affected blood and lymph nodes were under strong oxidative stress.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Péter Vajdovich, Tamás Kriska, Miklós Mézes, Piroska Ribiczey Szabó, Nándor Balogh, András Bánfi, Attila Arany-Tóth, Tibor Gaál, Judit Jakus,