Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10900464 | Cancer Letters | 2005 | 7 Pages |
Abstract
The RAD52 gene is involved in the homologous recombination repair pathway and is a plausible candidate ovarian cancer predisposition gene. We undertook a case-control comparison of 508 epithelial ovarian cancer cases (91 low malignant potential and 417 invasive) and 298 healthy controls to assess the RAD52 Y415X polymorphism as a risk factor for epithelial ovarian cancer in Australian women. Heterozygote frequencies of 2.6 and 4% were observed among cases and controls, respectively. The risk estimate was 0.55 (95%CI 0.24-1.24), suggesting that the RAD52 Y415X polymorphism is not associated with epithelial ovarian cancer in Australian women.
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Cancer Research
Authors
Livia Kelemen, Amanda B. Spurdle, David M. Purdie, Dorota Gertig, Georgia Chenevix-Trench,