Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10900551 | Cancer Letters | 2005 | 6 Pages |
Abstract
The expression of the c-kit protooncogene in human hepatocellular carcinoma (HCC) was investigated. Immunohistochemical staining (IHC) and RT-PCR were employed to examine the protein and mRNA expression of c-kit protooncogene, respectively. IHC results demonstrated that 22 of 86 (25.6%) HCC tissue sections expressed c-kit protein. The c-kit mRNA transcript was further confirmed in all 22 IHC c-kit positive HCC tissue samples by RT-PCR. Moreover, the relationship between c-kit expression in HCC and prognosis of patients was statistically analyzed and a correlation was established. The group of patients whose HCC specimens showed positive c-kit staining exhibited better survival as compared to those patients with negative c-kit expression (p=0.021). These results suggest that c-kit expression may be a good prognostic indicator for HCC.
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Authors
Chih-Yuan Chung, Kun-Tu Yeh, Nicholas C. Hsu, Julia Huei-Mei Chang, Jen-Tsun Lin, Huey-Ching Horng, Cheng-Shyong Chang,