Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10901045 | Cancer Letters | 2016 | 4 Pages |
Abstract
Myeloid derived suppressor cells (MDSCs) are a group of immature myeloid cells accumulated in most cancer patients and mouse tumor models. MDSCs suppress host immune response and concurrently promote tumor angiogenesis, thereby promote tumor growth and progression. In this review, we discuss recent progresses in expansion and activity of tumor MDSCs, and describe new findings about immunosuppressive function of different subtypes of MDSCs in cancer. We also discussed tumor angiogenic activities and pro-tumor invasion/metastatic roles of MDSCs in tumor progression.
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Cancer Research
Authors
Peng Qu, Li-zhen Wang, P. Charles Lin,