| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10901890 | Cancer Letters | 2015 | 11 Pages |
Abstract
- PKA is a multi-unit serine-threonine protein kinase existing in two isoforms, PKAI and PKAII.
- PKAI has long been implicated in tumor initiation, progression, and poor prognosis.
- PKAI also contributes to tumor immunoescape.
- Summarizing the dichotomous role of PKAI in the tumor milieu, and its 'two-in-one' chemoimmunotherapeutic manipulation.
Keywords
Tr1LPAGM-CSFTGFS1PEGFRGPCRspKaTregRIIbFGFCOXTNFMDR3LLnatural killercAMPG-protein coupled receptorsCatalytic subunitATPCyclic adenosine monophosphateadenylyl cyclasecyclooxygenaseSphingosine-1-phosphatelysophosphatidic acidAnti-tumor immunityimmunosurveillanceinterferonIFNinterleukintransforming growth factorT regulatory cellsGranulocyte macrophage colony stimulating factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)basic fibroblast growth factortumor necrosis factorlymphokine-activated killerLAKMultidrug resistanceprotein kinase AprostaglandinLewis lung carcinomaEpidermal growth factor receptor
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Cancer Research
Authors
Muzammal Hussain, Fei Tang, Jinsong Liu, Jiancun Zhang, Aqeel Javeed,