| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10902388 | Cancer Letters | 2014 | 10 Pages |
Abstract
- Pt complexes could enhance the anticancer efficacy of X-ray.
- Pt complexes inhibit TrxR activity to promote ROS overproduction.
- ROS-mediated signaling pathways contribute to the radiosensitization effects.
Keywords
2′, 7′-dichlorofluorescein diacetatePBSTrxRTrxDCF-DABCA3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromideDMSOG2/M arrestMTTROSSERbicinchoninic acidthioredoxin reductasethioredoxinSensitizersdihydroethidiumDimethyl sulfoxideRadiotherapyPlatinum complexesPhosphate-buffered salineDHEPropidium iodidePlatinumReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Qiang Xie, Guoqiang Lan, Yangliang Zhou, Jiamin Huang, Yuanwei Liang, Wenjie Zheng, Xiaoyan Fu, Cundong Fan, Tianfeng Chen,