| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10902427 | Cancer Letters | 2014 | 7 Pages |
Abstract
TFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3â²UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer.
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Authors
Jingjing Liu, Xu Wang, Xiaoning Yang, Yunpeng Liu, Ying Shi, Jianlin Ren, Bayasi Guleng,