Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10902459 | Cancer Letters | 2005 | 7 Pages |
Abstract
To clarify the modifying effect of the codon 72 p53 polymorphism on hepatocellular carcinoma (HCC) stratified by chronic hepatitis B virus (HBV) infection status, 111 incident cases of HCC and 424 controls in HBV-negative subjects and 135 cases and 125 controls in HBV-positive subjects were identified. No correlation between the polymorphism and HCC risk was found when comparing the HBV-positive cases to controls. However, in HBV-negative subjects, Arg/Pro and Pro/Pro genotypes had a 1.97-fold and a 3.36-fold increased risk for HCC, respectively. In subjects with the Pro allele and family history of HCC yielded an 11.81-fold increased risk of HCC.
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Authors
Zhong-Zheng Zhu, Wen-Ming Cong, Shu-Fang Liu, Zhi-Hong Xian, Wei-Qing Wu, Meng-Chao Wu, Bin Gao, Li-Fang Hou, Guan-Shan Zhu,