Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10902480 | Cancer Letters | 2005 | 6 Pages |
Abstract
In this study, we investigated whether expression of vascular endothelial growth factor (VEGF)-C and/or VEGF-D correlates with clinicopathological features of human gastric carcinoma. We immunohistochemically examined the expression of VEGF-C and VEGF-D in 140 archival surgical specimens of submucosally invasive gastric carcinoma. Of these specimens, 32 (22.9%) and 12 (8.6%) showed intense VEGF-C and VEGF-D immunoreactivity in cancer cells, respectively. VEGF-C immunoreactivity was associated with histological type, lymphatic invasion, lymph node metastasis, and microvessel density. No association was identified between VEGF-D immunoreactivity and clinicopathological variables. These results suggest that VEGF-C is a dominant regulator of lymphangiogenesis in early-stage human gastric carcinoma.
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Authors
Seiji Onogawa, Yasuhiko Kitadai, Toru Amioka, Michiyo Kodama, Songde Cho, Tsuyoshi Kuroda, Takehiko Ochiumi, Shigeru Kimura, Toshio Kuwai, Shinji Tanaka, Kazuaki Chayama,