Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10903226 | Cancer/Radiothérapie | 2005 | 6 Pages |
Abstract
Optimal management of intracranial germinomas remains controversial. Focal irradiation to the primary tumor followed by prophylactic craniospinal radiotherapy represents the traditional treatment resulting in excellent long-term survival but potential late effects. To decrease late effects related to extensive fields of radiotherapy, combined chemotherapy and irradiation has been tested with reduced volumes and doses of radiation therapy. We report our experience about four patients successfully treated by neoadjuvant chemotherapy with carboplatin and etoposide followed by radiotherapy delivering 26 to 36Â Gy to the whole brain and 36 to 50Â Gy to the initial tumor volume.
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Authors
L. Védrine, O. Bauduceau, M. Fayolle, S. Le Moulec, B. Ceccaldi,