| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10903799 | Experimental Cell Research | 2015 | 7 Pages |
Abstract
Lysophosphatidic acid (LPA) is a lipid mediator that modulates a wide variety of cellular functions. Elevated LPA signaling has been reported in patients with colorectal cancer or inflammatory bowel diseases, and the tumorigenic role of LPA has been demonstrated in experimental models of colon cancer. However, emerging evidence indicates the importance of LPA signaling in epithelial wound healing and regulation of intestinal electrolyte transport. Here, we briefly review current knowledge of the biological roles of LPA signaling in the intestinal tract.
Keywords
LPANa+/H+ exchanger regulatory factorPLC-βNa+/H+ exchanger 3RhoGEFYAMCNHERFNHE3Klf5Phospholipase C-βRho guanine nucleotide exchange factorAutotaxinATXCFTRIBDMMPDSSFAKPLAHIF-1COX-2phosphatidic acidlysophosphatidic acidinflammationInflammatory bowel diseaseIntestineColorectal cancerColon cancerintestinal epithelial celldextran sodium sulfateCyclooxygenase-2MIFhypoxia-inducible factor 1kruppel-like factor 5Macrophage migration inhibitory factorphospholipase AMatrix metalloproteaseCRCIECfocal adhesion kinase
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Authors
C. Chris Yun, Ajay Kumar,