Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10903909 | Experimental Cell Research | 2015 | 10 Pages |
Abstract
MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers.
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Authors
Ying-fei Lu, Li Zhang, Mary Miu Yee Waye, Wei-ming Fu, Jin-fang Zhang,