Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10904003 | Experimental Cell Research | 2014 | 8 Pages |
Abstract
- Newly identified interactions with the FHA and BRCT domains of NBS1 influence subcellular localization of the MRE11 complex.
- The MRE11 complex promotes TOPBP1 recruitment and ATR activation during replication stress.
- The MRE11 complex is a barrier to oncogene-induced tumorigenesis.
Keywords
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Authors
Katrin Rein, Travis H. Stracker,