Sorafenib enhances proteasome inhibitor-mediated cytotoxicity via inhibition of unfolded protein response and keratin phosphorylation

Article ID	Journal	Published Year	Pages	File Type
10904285	Experimental Cell Research	2013	13 Pages	PDF

Keywords

UPR 4', 6-diamidino-2-phenylindole Poly-ADP-ribose-polymerase Mallory–Denk body GADD153 PDGFR IRE ALLN VEGFR TRAF2 PARP LC3 XBP1 DAPI eIF2 ATF Jnk MDB GFP mTOR C/EBP homologous protein c-Jun N-terminal kinase HCC MAPK PKR-like ER kinase Autophagy Endoplasmic reticulum stress CHOP Apoptosis light chain 3 endoplasmic reticulum activating transcription factor Proteasome inhibitor Necrosis mammalian target of rapamycin Antibody Unfolded protein response X-box binding protein 1 green fluorescent protein mitogen-activated protein kinase PERK Hepatocellular carcinoma Keratin platelet-derived growth factor receptor vascular endothelial growth factor receptor

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Sorafenib enhances proteasome inhibitor-mediated cytotoxicity via inhibition of unfolded protein response and keratin phosphorylation

Authors

Yuichi Honma, Masaru Harada,