Article ID Journal Published Year Pages File Type
10904300 Experimental Cell Research 2013 19 Pages PDF
Abstract
Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumor cells and their microenvironment. The ability of CAFs to orchestrate tumor-promoting inflammation is central to their role in facilitating tumor growth, invasion, and metastasis. Here we review pathways by which CAFs and their soluble mediators provide multiple complex signals that modulate the recruitment, functional activation status, and retention of immune cells in the tumor microenvironment.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
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